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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex ...

Author : Gerard Socie

Release : 2018-11-22

Publisher : Academic Press

ISBN : 0128134399

File Size : 40.87 MB

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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Allogeneic Stem Cell Transplantation Using HLA-matched Donors for Acute Myeloid Leukemia with Deletion 5q Or Monosomy 5

Abstract: Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation.

Author : Xavier Poiré

Release : 2020

Publisher :


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Abstract: Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation

Allogeneic Stem Cell Transplantation

In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in ...

Author : Hillard M. Lazarus

Release : 2010-03-02

Publisher : Springer Science & Business Media

ISBN : 9781597454780

File Size : 76.17 MB

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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Hematopoietic Stem Cell Transplantation

Francine Foss and Koen van Besien 9.1 Alternative Conditioning Regimens for
Allogeneic Hematopoietic Stem Cell Transplantation Preparative regimens for
allogeneic hematopoietic stem cell transplantation (HSCT) must address two ...

Author : Michael R. Bishop

Release : 2009-09-25

Publisher : Springer Science & Business Media

ISBN : 9780387785806

File Size : 67.42 MB

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The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

... malignant, dendritic cell—prepared vaccination in, 297, 298 Melphalan, in mini
-transplant, 102–103 Methotrexate, in allogeneic peripheral blood stem cell
transplantation, 138 Methylprednisolone, in allogeneic peripheral blood stem cell

Author : Richard K. Burt

Release : 2012-11-28

Publisher : Springer

ISBN : 1461549876

File Size : 79.56 MB

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The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Donor Cell Derived Deletion 7q Occurring After Allogeneic Stem Cell Transplantation: a Case Report

IntroductionDeletion 7q (del(7q)) is a non-reciprocal chromosomal abnormality frequently seen in patients with therapy related myeloid neoplasms.

Author : Anke Delie

Release : 2017

Publisher :


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IntroductionDeletion 7q (del(7q)) is a non-reciprocal chromosomal abnormality frequently seen in patients with therapy related myeloid neoplasms. The resulting compound haploinsufficiency and dysregulation of gene expression is thought to play a key role in disease development and progression in myeloid malignancies. Deletion 7q has been found to be a recurrent genetic abnormality in donor cell leukemia (DCL) and u2013MDS. Case presentationWe present a case of donor cell derived del(7q) occurring in a 61 year old male 4 years after a matched related donor allogeneic stem cell transplantation for a poor risk acute myeloid leukemia (FLT3-ITD+, NPM-). Pre-transplant bone marrow aspirate showed a complete morphological and molecular remission without any cytogenetic abnormalities. On pre-donation screening, peripheral blood counts of the donor (the patients HLA-identical sister) showed no abnormalities. Post-transplant course was complicated by the occurrence of a primo CMV-infection and a transient clonal expansion of T-cell large granular lymphocytes. Routine bone marrow analysis 4 years post-transplant identified a del(7q) in 10 out of 20 cells, all of them with female karyotype (46,XX,del(7)(q21)[10]), alongside normal morphology and full donor chimerism. The donor was contacted and bone marrow analysis performed, showing no morphological or cytogenetic abnormalities. DiscussionThe mechanism of development of del(7q) in our patient is unclear. Taking into account the normal karyotype in the donor as well as the long latency between transplant and development of the abnormality, it seems likely that host factors such as an impaired bone marrow microenvironment, an underlying genetic predisposition or defective immune surveillance played a significant role in the development of the observed abnormality. ConclusionAs there is a high risk of further clonal evolution to donor cell derived MDS or DCL strict further follow-up is warranted. The detection of donor cell derived clonal abnormalities should warrant a thorough evaluation of the donor.

Pediatric Stem Cell Transplantation

HSCT can be classified into two main categories : allogeneic and autologous . In
allogeneic transplantation , the patient receives hematopoietic stem cells from a
donor other than himself . In autologus transplatation , the patient receives his ...

Author : Paulette Mehta

Release : 2004

Publisher : Jones & Bartlett Learning

ISBN : 9780763718558

File Size : 32.32 MB

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This textbook examines stem cell transplatation in pediatric patients.

Blood and Marrow Stem Cell Transplantation

Hematopoietic Stem Cell Transplant Immunology For the last two decades or so ,
our understand ... an otherwise lethal dose of X rays to the whole body they can
recover if injected intravenously with homologous ( allogeneic } myeloid cells .

Author : Susan Ezzone

Release : 2007

Publisher : Jones & Bartlett Learning

ISBN : 9780763747190

File Size : 46.40 MB

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Blood and Marrow Stem Cell Transplantation, Third Edition serves as a convenient reference for oncology nurses caring for blood and marrow stem cell transplantation recipients. The Third Edition has been updated and revised to reflect the most current research related to the past, present, and future of blood and marrow stem cell transplants. This resource covers everything from preparing for transplantation surgery, to recovery-related issues and delayed outcomes. Basic background information on transplantation procedures and processes are provided, along with in-depth coverage of pulmonary, cardiac, renal and hepatic, neurologic, and hematologic effects. A chapter devoted to controversial ethical issues is also provided. Blood and Marrow Stem Cell Transplantation, Third Edition presents complete, up-to-date coverage of the transplantation process from beginning to end.

Unrelated Donor Choices for Allogeneic Hematopoietic Cell Transplantation in Canada: an Evaluation of Factors Influencing Donor Selection

CBU). RESULTS: HLA‐matched donors within OM and/or international (INT) registries were preferentially investigated, underscoring the primary importance of HLA matching.

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Release : 2017

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Abstract : BACKGROUND: Utilization of unrelated donors and cord blood units (CBUs) for allogeneic hematopoietic cell transplantation continues to increase. Understanding the practices of donor selection by transplant centers is critical for unrelated donor registries and cord blood banks to optimize registry composition and inventory to meet patient need. STUDY DESIGN AND METHODS: Unrelated donor and CBU selection practices of Canadian transplant centers served by Canadian Blood Services' OneMatch Stem Cell & Marrow Network (OM) were reviewed, including HLA match level, locus of disparity, age, sex, and product choice (donor vs. CBU). RESULTS: HLA‐matched donors within OM and/or international (INT) registries were preferentially investigated, underscoring the primary importance of HLA matching. In the case of HLA‐mismatched donors, HLA‐A disparities were most common while DRB1 mismatches were least common. Advanced age, sex, and lack of donor availability were the most frequent reasons that high‐probability OM donors were overlooked in favor of INT donors. High‐probability 10 of 10 HLA‐matched female donors from OM were often avoided in favor of INT male donors. Use of female donors, however, increased in cases restricted to more HLA‐disparate donor options. Caucasian patients were more likely to find 10 of 10 matched donors, whereas use of mismatched donors and CBUs were more prevalent among non‐Caucasian patients. CONCLUSIONS: Recruitment and retention of young, male donors from diverse ethnic backgrounds may increase the usage of histocompatible OM donors for patients in need.

Hematopoietic Stem Cell Transplantation

Stem. Cells. for. Allogeneic. Transplantation. LUTZ UHAREK and MATTHIAS
ZEIS University of Leipzig, Leipzig, Germany PETER DREGER, BERTRAM
GLASS, and NORBERT SCHMITZ Christian Albrechts University of Kiel, Kiel,
Germany I.

Author : Anthony D. Ho

Release : 2000-07-25

Publisher : CRC Press

ISBN : 9780824741815

File Size : 58.92 MB

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This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Transplant Infections

Risk factors in pediatric stem cell transplantation for leukemia. Pediatr Transplant.
2004;8:464–474. 105. Avetisyan G, Aschan J, Hagglund H, et al. Evaluation of
intervention strategy based on CMV-specific immune responses after allogeneic

Author : Raleigh A. Bowden

Release : 2012-03-28

Publisher : Lippincott Williams & Wilkins

ISBN : 1451148097

File Size : 80.70 MB

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Transplant Infections is a practical, clinically focused reference covering the common and more unusual bacterial, viral, and fungal infections affecting patients who have received stem cell or solid organ transplants. It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. Highlights of the Third Edition include a chapter on new immunosuppressive agents and expanded coverage of tropical infections and West Nile virus.

Bone Marrow and Stem Cell Transplantation

... and Relapse by Lineage-Specific Chimerism Analysis Thomas Lion Summary
Molecular surveillance of hematopoietic chimerism has become part of the
routine diagnostic program in patients after allogeneic stem cell transplantation.

Author : Meral Beksaç

Release : 2007-05-03

Publisher : Springer Science & Business Media

ISBN : 1588295958

File Size : 37.30 MB

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Molecular Methods: Stem Cell Transplantation presents a compendium of cutting-edge research on the molecular steps involved in hematopoietic stem cell (HSC) activation and self-renewal. The emergence of HLA typing, and the positive impact it has had on the success of clinical transplantation is emphasized and discussed by notable stem cell researchers.

Hematopoietic Stem Cell Transplantation Research Advances

The other approach to reduce relapse is allogeneic HSCT ( allo - HSCT ) through
graft - versus - lymphoma ( GVL ) effect . The GVL effect ... Recently ,
reducedintensity stem cell transplantation ( RIST ) has opened a new era for allo
- HSCT .

Author : Karl B. Neumann

Release : 2008

Publisher : Nova Publishers

ISBN : 9781604560428

File Size : 69.16 MB

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Hematopoietic stem cell transplantation (HSCT) is the transplantation of blood stem cells derived from the bone marrow (that is, bone marrow transplantation) or blood. Stem cell transplantation is a medical procedure in the fields of haematology and oncology, most often performed for people with diseases of the blood, bone marrow, or certain types of cancer. Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognised with a Nobel Prize in Physiology and Medicine. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease. With the availability of the stem cell growth factors GM-CSF and G-CSF, most hematopoeitic stem cell transplantation procedures are now performed using stem cells collected from the peripheral blood, rather than from the bone marrow. Collecting stem cells provides a bigger graft, and does not require that the donor be subjected to general anaesthesia to collect the graft. Hematopoeitic stem cell transplantation remains a risky procedure with many possible complications; it has always been reserved for patients with life-threatening diseases. This book presents recent leading research in the field.

Thomas' Hematopoietic Cell Transplantation

Bone Marrow Transplant 2005; 35: 437–40. 6. Bornhauser M, Storer B, Slattery
JT et al. Conditioning with fludarabine and targeted busulfan for transplantation
of allogeneic hematopoietic stem cells. Blood 2003; 102: 820–6. 7. Tauro S ...

Author : Frederick R. Appelbaum

Release : 2011-09-26

Publisher : John Wiley & Sons

ISBN : 144435745X

File Size : 26.65 MB

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This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases. The book also now includes a fully searchable CD with PDFs of the entire content.


Cho BS, Lee S, Kim YJ, et al. Reduced-intensity conditioning allogeneic stem cell
transplantation is a potential therapeutic approach for adults with high-risk acute
lymphoblastic leukemia in remission: results of a prospective phase 2 study.

Author :

Release : 2011-08-29

Publisher : Demos Medical Publishing

ISBN : 1935281429

File Size : 44.13 MB

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This issue of Emerging Cancer Therapeutics provides a comprehensive review for practitioners on the current status of leukemia treatment. Leukemia treatment has undergone major change over the course of the past few years and Leukemia addresses current best practices in the light of the most recent evidence. With contributions from experts across the US and Canada, Leukemia details the current management of different types of leukemia and reviews new therapies in development for various forms of acute leukemia, chronic leukemia, myelodysplastic syndrome, and myeloproliferative disorders. Coverage includes new developments in hematopoitic cell transplantation, leukemia pathology and management, immunotherapy and targeted therapies. It is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows. Emerging Cancer Therapeutics Series Titles Features: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice

Hodgkin's Lymphoma, An Issue of Hematology/Oncology,

Reduced-intensity conditioning for allogeneic haematopoietic stem cell
transplantation in relapsed and refractory Hodgkin lymphoma: impact of
alemtuzumab and donor lymphocyte infusions on long-term outcomes. Br J
Haematol 2007 ...

Author : Volker Diehl

Release : 2014-02-09

Publisher : Elsevier Health Sciences

ISBN : 0323266614

File Size : 24.15 MB

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This issue of Hematology/Oncology Clinics is focused on Hodgkin's Lymphoma and covers such topics as First HRS-cell line L428 and the detection of the CD-30 Antigen , “Normal“ CD30-B-lymphocytes, CD-30-Antigen, Combination-Chemo-Radiotherapy, Early intensification (escBEACOPP), Customized/Targeted Therapy, and more.

Unanswered Questions in Oral and Maxillofacial Infections, An Issue of Oral and Maxillofacial Surgery Clinics - E-Book

Central (continued) brain abscess, 574–577 cavernous sinus thrombosis, 570–
573 Costs, of oral antibiotics for odontogenic infections, 529, 531
Cytomegalovirus, orofacial, in patients receiving allogeneic stem cell
transplantation, 582–583 D ...

Author : Thomas R. Flynn

Release : 2012-01-09

Publisher : Elsevier Health Sciences

ISBN : 1455709425

File Size : 75.37 MB

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This special issue will review the many unanswered questions regarding oral and maxillofacial infections. Questions include: Should we extract teeth in the presence of infection? Should we wait for development of an abscess before we perform incision and drainage? What are the antibiotics of choice for odontogenic infections, and how long should the treatment course last? Is clindamycin losing its effectiveness in odontogenic infections? Should we use prophylactic antibiotics for removal of erupted teeth, impacted teeth, dental implants, or other dentoalveolar surgery? How can we as dentists minimize our contribution to the problem of antibiotic resistance? How will culture and antibiotic sensitivity testing be done in the foreseeable future? How can osteomyelitis of the jaws be diagnosed at the earliest possible time? How should the practicing oral and maxillofacial surgeon manage cases of odontogenic deep neck infections that extend beyond his/her area of expertise? Do dental infections really cause central nervous system infections? What are the lessons we can glean from review of recent closed malpractice cases involving oral and maxillofacial infections? How do we manage oral infections in the severely immunocompromised host, such as in chemotherapy for blood cancers or in bone marrow transplant patients? What is the role of biofilms in severe head and neck infections? How strong is the evidence supporting oral inflammation as a cause of systemic disease?

Acute Care Oncology Nursing

Graft versus host disease (GVHD) is a frequent complication of allogeneic stem
cell transplantation and a much rarer complication of blood transfusions. The
conditions for GVHD are met when immunocompetent donor cells are introduced
into ...

Author : Cynthia C. Chernecky

Release : 2009

Publisher : Elsevier Health Sciences

ISBN : 1416037349

File Size : 43.93 MB

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As the likely first responder in an emergency, you need quick access to essential information on the potential complications of many different cancer types and treatments. The new edition of this trusted resource provides up-to-date information on the pathophysiology, complications, risks, treatment approaches, prognosis, assessment findings, and nursing and medical interventions for a wide range of cancers. It also offers valuable information to help you fulfill your role as care coordinator and patient advocate, including client education guidelines, discharge procedures, and strategies for helping the client and family deal with the impact of the disease's progression. A consistent format throughout helps you quickly find the information you need, no matter what the topic. This indispensable reference is written and reviewed by both oncology and acute care nurses, ensuring accuracy, currency, and clinical relevance. Coverage of each cancer includes pathophysiologic mechanisms, epidemiology and etiology, risk profile, prognosis, professional assessment criteria (PAC), nursing care and treatment, evidence-based practice update, patient teaching, nursing diagnoses or DSM-IV, evaluation and desired outcomes, and discharge planning with follow-up care, where needed. The latest prognosis statistics give you a realistic picture of the survival possibilities for your patients so you can provide the most appropriate nursing care and patient education. Multiple-choice review questions with answers and rationales at the end of each chapter help reinforce your understanding of key concepts and prepare you for certification examinations. Special boxes highlight pediatric-specific care considerations for working with children. Six new chapters - Biliary and Pancreatic Obstruction, Depression and Cognitive Dysfunction, Dyspnea and Airway Obstruction, GI Obstruction, Heart Failure, and Spiritual Distress - keep you up to date with the latest advances in oncology nursing. Evidence-based rationales in the nursing interventions help you apply the latest research findings to actual practice. Each chapter includes a new section on pathophysiology to help you understand the physiologic processes associated with each oncologic complication.

Non-Myeloablative Allogeneic Transplantation

NST ) IN THE TREATMENT OF ... Arnon Nagler DISCUSSION Allogeneic
hematopoietic stem - cell transplantation ( HSCT ) is an effective , potentially
curative ...

Author : Asad Bashey

Release : 2002-02-28

Publisher : Springer Science & Business Media

ISBN : 9780792376460

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Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.