Pubpsher: Karger Medical and Scientific Publishers
This book unfolds the history of the discovery of the transmembrane channel which is responsible for the 'funny' or If current, the primary modulator of heart rate. Inhibition of this current leads to slowing of the heart rate, which is an important component of the successful management of angina pectoris. Recently, Ivabradine, a specific and selective inhibitor of the If current, has been developed as an antianginal agent which has been shown to be at least as effective as both beta-blockers and calcium channel blockers for the treatment of angina. The development, efficacy and complications of this therapy are discussed in detail in this book. Furthermore, the clinical benefits from heart rate reduction in patients with coronary artery disease and heart failure and in patients after myocardial infarction are examined. Whether a lower heart rate per se will prolong life is not yet known, but it may offer a new and important life-saving strategy. The current data presented in this volume will be appreciated by cardiologists and general physicians interested in the modern management of angina pectoris and by electrophysiologists and physiologists who would like to understand the importance of heart rate and its regulation.
What if children happily went to bed on time every night? Impossible? Probably. But this delightful book will help make bedtime a fun time for everyone. What If? features a little boy who uses his fantastic imagination to delay bedtime for as long as possible: ?What if all the trees would suddenly shrink until they were the size of flowers, and I could pick a bouquet just for you, Mom.' While reading this enchanting, dream-aloud bedtime story, children will have great fun imagining ?what ifs? of their own. Be sure not to miss the special glow-in-the-dark dream page in the back of the book.
Includes the following features: sample lesson plans, pre-reading activities, biographical sketch and picture of the author, book summary, vocabulary lists and vocabulary activity ideas, quizzes, hands-on projects, cooperattive learning activities, cross-curricular activities, post-reading activities, book report ideas and research ideas.
During the last three decades, interest has increased significantly in the representation and manipulation of imprecision and uncertainty. Perhaps the most important technique in this area concerns fuzzy logic or the logic of fuzziness initiated by L. A. Zadeh in 1965. Since then, fuzzy logic has been incorporated into many areas of fundamental science and into the applied sciences. More importantly, it has been successful in the areas of expert systems and fuzzy control. The main body of this book consists of so-called IF-THEN rules, on which experts express their knowledge with respect to a certain domain of expertise. Fuzzy IF-THEN Rules in Computational Intelligence: Theory and Applications brings together contributions from leading global specialists who work in the domain of representation and processing of IF-THEN rules. This work gives special attention to fuzzy IF-THEN rules as they are being applied in computational intelligence. Included are theoretical developments and applications related to IF-THEN problems of propositional calculus, fuzzy predicate calculus, implementations of the generalized Modus Ponens, approximate reasoning, data mining and data transformation, techniques for complexity reduction, fuzzy linguistic modeling, large-scale application of fuzzy control, intelligent robotic control, and numerous other systems and practical applications. This book is an essential resource for engineers, mathematicians, and computer scientists working in fuzzy sets, soft computing, and of course, computational intelligence.
Let's face it--lust can seriously impair your judgement. It's hard enough for most women to meet a sane, single, straight specimen--who has time to psychoanalyze a hot new guy on the horizon? Enter award-winning illustrator Patricia Carlin's edgy, impulse-dating humour guide for the hip, young and urban.A cross between The Diagnostic and Statistical Manual of Mental Disorders, The Rules and He's Just Not That Into You, it teaches women to identify the warning signs associated with a spectrum of Mr. Wrongs, from cult leaders to polygamists, Trekkies, zombies and slackers.